Adam Friedman, MD, Professor and Chair of Dermatology at the George Washington University School of Medicine & Health Sciences in Washington, DC, and Dermatology Nurse Practitioner Melodie Young, MSN, ANP-c, a Dermatology Nurse Practitioner at Mindful Dermatology, a Baylor-Health Texas Affiliate, in Dallas, TX, review two challenging seborrheic dermatitis cases. They discuss the importance of making a differential diagnosis of this common inflammatory skin condition which can mimic sebopsoriasis or other cutaneous diseases.