IKBKB Genetic Mutation Implicated in PsO, PsA

A mutation in the IKBKB gene may cause psoriasis, new research suggests.

And if two copies of this mutated gene are present, patients with psoriasis may go on to develop psoriatic arthritis, the researchers report.

“Using a mouse model, we identified that this mutation led to an abnormal function in a group of immune cells known as regulatory T cells,” says researcher Chelisa Cardinez, PhD, of the Australian National University John Curtin School of Medical Research, in a news release. “These cells are normally considered gatekeepers of the immune system. However, we found that this mutation alters the function of these cells, causing them to contribute to inflammation and promote the onset of disease.”

Dr Cardinez adds, “Studies have shown that delays in psoriatic arthritis diagnosis is linked to worse clinical outcomes for patients. Therefore, earlier detection and treatment of these immune diseases is key to improving health outcomes.

“By developing a better understanding of the IKBKB gene and the role it plays in promoting the onset of these diseases, it could bring us a step closer to one day finding a cure.”

The research is published in Nature Communications.