Allergan Aesthetics is developing trenibotulinumtoxinE as a “try-before-you-buy” toxin because it starts working within eight hours and these effects are gone in about two weeks. Here, Rosalyn George, MD, a Dermatologist in Wilmington, NC, reviews top-line data from a Phase 3 study looking at the safety and efficacy of trenibotulinumtoxinE for smoothing glabellar lines in toxin-naïve participants. She presented these findings at the 2025 Annual Meeting of the American Society for Dermatologic Surgery (ASDS) in Chicago, IL.