A new cannabidiol (CBD)-based topical can reduce Ultraviolet A (UVA)-induced DNA damage at the cellular level, preventing both nuclear and mitochondrial DNA mutations associated with accelerated skin aging and skin cancer, according to a study in the Journal of the American Academy of Dermatology (JAAD).
Delivered via nanotechnology, the product, CielementsMD DNA Defense Daily Cream, comprises patented CannaXR (extended release) CBD cream. It works with sunscreen to prevent photoaging and lower skin cancer risk.
The next issue of TDD features an article the development of this product with the inventor of the nanotechnology Adam Friedman, MD, Professor and Chair of Dermatology at The George Washington University School of Medicine and Health Sciences in Washington, DC.
Key findings from the study include:
- 21% less erythema(skin redness) in CannaXR-treated areas after exposure to 3x the amount of UVA needed to burn the skin.
- Reduced epidermal skin thickening and damage(a sign of early UV skin damage)
- Fewer sunburn cellsand lower OGG1 staining (a biomarker for free radical DNA damage)
Cellular-Level Defense:
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- Reduced the expected and harmful nuclear DNA base lesionsfrom UVA exposure
- Significantly fewer mitochondrial DNA mutations, particularly in ND1 and ND4—key genes implicated in skin aging and UV-related cancer risk
“This landmark study represents a major advance in dermatological protection and anti-aging science,” says study author Brian Berman, MD, PhD, Co-Director Center for Clinical and Cosmetic Research in Avebntura, FL and Professor Emeritus of Dermatology and Dermatologic Surgery at The University of Miami Miller School of Medicine in Miami, FL. “With skin cancer still the most diagnosed cancer in the U.S., solutions like CannaXR that demonstrate molecular protection are a vital step forward.”
