The 2025 Music City (SCALE) Symposium for Cosmetic Advances and Laser Education meeting, held from May 14 to 18 in Nashville, TN, hit all the high notes. Here, Meeting Co-founder Michael H. Gold, MD, gives a recap of key talks including “Cellular Senescence and Senolytics: Implications for Aesthetic Medicine” by James L. Kirkland, MD, PhD, a Professor of Physiology and Professor of Medicine at Mayo Clinic in Rochester, MN, “The Skin-Brain Axis and Its Subconscious Influence on Mind, Mood, and Sexuality” by Steven Dayan, MD, a Facial Plastic Surgeon on Chicago, plus much more.