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Treg Hypothesis Validated in Inflammatory Skin Diseases: Rezpegaldesleukin Shows Promise in AD, PsO

Rezpegaldesleukin showed durable dose-dependent improvements in physician-assessed disease activity and patient-reported outcomes in patients with atopic dermatitis (AD) and psoriasis (PsO), according to two Phase 1b studies in Nature Communications. Under development as a self-administered injection, rezpegaldesleukin is a first-in-class interleukin-2 receptor (IL-2R) agonist that enhances the activity of regulatory T cells (Tregs). It is wholly-owned by Nektar Therapeutics. […]