Elucidating the Role of HIF-1-alpha in Psoriasis
The interleukin-17 (IL-17) pathway activates hypoxia-inducible factor 1-alpha (HIF-1-alpha) in psoriasis, according to a new study in Immunity. The research team also found that HIF-1-alpha let inflamed skin cells more actively break down sugar for energy, supporting their metabolism and leading to the production of a waste product called lactate. When consumed by inflammatory T cells, […]