Exploring the Tumor Suppressor Activity of the PTEN Protein in Melanoma
Scientists have made significant progress in understanding the molecular mechanisms leading to melanoma development, but precisely how the PTEN protein regulated melanoma progression was unclear until now. In a new study published in Cancer Research, Moffitt Cancer Center researchers showed how the antitumor activity of PTEN suppresses the cancer-promoting activity of the FRA1 transcription factor through the AKT signaling pathway. Mutations […]